Antinociceptive, Antipyretic and Antimicrobial Activities of Chrozophora tinctoria Extracts
By: Sher, A. A
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Contributor(s): Bakht, J | Khan, K.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2018Edition: Vol. 80(03), September-October.Description: 533-540.Subject(s): PHARMACEUTICS | Antibacterial | Antifungal | Antipyretic | Chrozophora tinctoriaOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: The antinociceptive, antipyretic and antimicrobial activities possessed by different solvent extracts of Chrozophora tinctoria were investigated. Analgesic activity of the crude methanol extract was studied using the hot plate and acetic acid-induced writhing methods and antipyretic activity using standard procedures on mice. C. tinctoria extract had highest latency time on the hot plate. The plant extracts reduced the number of abdominal constriction by 50 % at a dose of 150 mg/kg. The antipyretic effect of all doses tested was comparable to that of normal saline. Maximum decrease in the body temperature of the mice was observed at a dose of 300 mg/kg extract. Ethyl acetate extract revealed good antibacterial potential against Salmonella typhi (83% inhibition) and Shigella sonnei (63 % inhibition). Chloroform extract showed highest antifungal activity against Rhizopus sp. (68 % inhibition).
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2018361 |
The antinociceptive, antipyretic and antimicrobial activities possessed by different solvent extracts of Chrozophora tinctoria were investigated. Analgesic activity of the crude methanol extract was studied using the hot plate and acetic acid-induced writhing methods and antipyretic activity using standard procedures on mice. C. tinctoria extract had highest latency time on the hot plate. The plant extracts reduced the number of abdominal constriction by 50 % at a dose of 150 mg/kg. The antipyretic effect of all doses tested was comparable to that of normal saline. Maximum decrease in the body temperature of the mice was observed at a dose of 300 mg/kg extract. Ethyl acetate extract revealed good antibacterial potential against Salmonella typhi (83% inhibition) and Shigella sonnei (63 % inhibition). Chloroform extract showed highest antifungal activity against Rhizopus sp. (68 % inhibition).
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